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Journal articles
30/01/2023 Journal article A hybrid effectiveness-implementation study protocol to assess the effectiveness and chemoprevention efficacy of implementing seasonal malaria chemoprevention in five districts in Karamoja region, Uganda The study aims to test the effectiveness and safety of DP-SMC and SPAQ-SMC among 3–59 months old children in Karamoja region, Uganda. 30/01/2023 The study aims to test the effectiveness and safety of DP-SMC and SPAQ-SMC among 3–59 months old children in Karamoja region, Uganda.
12/01/2023 Journal article Optimising the role of ‘lead mothers’ in seasonal malaria chemoprevention campaigns: Formative research in Kano state, northern Nigeria Lead mothers can and do influence caregivers to adopt healthy behaviours during SMC campaigns. But their recruitment, training and supervision can be improved. 12/01/2023 Lead mothers can and do influence caregivers to adopt healthy behaviours during SMC campaigns. But their recruitment, training and supervision can be improved.
01/07/2022 Journal article Digital molecular diagnostics for infectious diseases in sub-Saharan Africa The Digital Diagnostics for Africa Network have identified new technologies with the potential to bring the laboratory to the patient, wherever they may be. 01/07/2022 The Digital Diagnostics for Africa Network have identified new technologies with the potential to bring the laboratory to the patient, wherever they may be.
16/06/2022 Journal article A stakeholder group assessment of interactions between child health and the Sustainable Development Goals in Cambodia A group with different expertise and perspectives was assembled in Cambodia to score the linkages between the SDGs and child health. 16/06/2022 A group with different expertise and perspectives was assembled in Cambodia to score the linkages between the SDGs and child health.
16/06/2022 Journal article The private sector market for malaria rapid diagnostic tests in Nigeria: Results of the 2018 market survey Increasing household knowledge of rapid diagnostic tests (RDTs) may aid increasing demand, while subsidised RDTs may address supply and price issues. 16/06/2022 Increasing household knowledge of rapid diagnostic tests (RDTs) may aid increasing demand, while subsidised RDTs may address supply and price issues.
06/06/2022 Journal article Surveillance as a core intervention to strengthen malaria control programmes in moderate to high transmission settings Recent improvements in malaria surveillance have opened the possibility of transforming surveillance into a core intervention. 06/06/2022 Recent improvements in malaria surveillance have opened the possibility of transforming surveillance into a core intervention.
01/03/2022 Journal article Extending delivery of seasonal malaria chemoprevention to children aged 5–10 years in Chad: A mixed-methods study This study was conducted in Massaguet health district in Hadjer Lamis province, where SMC has been implemented since 2015. 01/03/2022 This study was conducted in Massaguet health district in Hadjer Lamis province, where SMC has been implemented since 2015.
12/02/2022 Journal article The impact of the private sector co-payment mechanism on the private market for ACT in Nigeria Supply of rapid diagnostic tests and artemisinin-based combination therapy (ACT) medicines needs to be synchronised to prevent high levels of ACT misuse. 12/02/2022 Supply of rapid diagnostic tests and artemisinin-based combination therapy (ACT) medicines needs to be synchronised to prevent high levels of ACT misuse.
04/12/2021 Journal article Does anthropogenic introduction of guppy fish impact faunal species diversity and abundance in natural aquatic habitats? This study assesses the potential impact on the diversity and abundance of faunal species by anthropogenic introduction of guppy fish. 04/12/2021 This study assesses the potential impact on the diversity and abundance of faunal species by anthropogenic introduction of guppy fish.
04/12/2021 Journal article Determinants of malaria testing at health facilities: The case of Uganda These findings underscore the need for malaria control programmes to provide regular supportive supervision to health facilities and training in rapid diagnostic testing. 04/12/2021 These findings underscore the need for malaria control programmes to provide regular supportive supervision to health facilities and training in rapid diagnostic testing.
22/11/2021 Journal article Health management information system data quality and associated factors in Massaguet district, Chad For quality assessment, data on children under 15 years were obtained from the health management information system and the external patient register. 22/11/2021 For quality assessment, data on children under 15 years were obtained from the health management information system and the external patient register.
25/10/2021 Journal article Impact of current malaria infection and previous malaria exposure on the clinical profiles and outcome of COVID-19 in a high malaria transmission setting Our co-infection study found that low previous malaria exposure was associated with severe or critical COVID-19 and adverse outcomes in a high burden malaria setting. 25/10/2021 Our co-infection study found that low previous malaria exposure was associated with severe or critical COVID-19 and adverse outcomes in a high burden malaria setting.
18/10/2021 Journal article Modelled impact of seasonal malaria chemoprevention on district-level suspected and confirmed malaria cases in Chad based on routine clinical data (2013–2018) This study presents a solution for employing readily available routine data to evaluate the impact of health interventions at scale without extensive covariate data. 18/10/2021 This study presents a solution for employing readily available routine data to evaluate the impact of health interventions at scale without extensive covariate data.
15/10/2021 Journal article A feasibility study to assess non-clinical community health workers’ capacity to use simplified protocols and tools to treat severe acute malnutrition in Niger state, Nigeria With training and supportive supervision, community-oriented resource persons can treat severe acute malnutrition in under-fives and refer complicated cases. 15/10/2021 With training and supportive supervision, community-oriented resource persons can treat severe acute malnutrition in under-fives and refer complicated cases.
17/09/2021 Journal article Assessment of the feasibility, acceptability and impact of implementing seasonal malaria chemoprevention in Nampula Province, Mozambique This study provides a unique contribution to the evidence on the prevalence of SPAQ resistance in Mozambique and will inform future SMC implementation. 17/09/2021 This study provides a unique contribution to the evidence on the prevalence of SPAQ resistance in Mozambique and will inform future SMC implementation.
09/09/2021 Journal article Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria The lack of pharmacokinetic data in young children with vivax malaria is a major evidence gap. This study aims to develop regimens to address this. 09/09/2021 The lack of pharmacokinetic data in young children with vivax malaria is a major evidence gap. This study aims to develop regimens to address this.
08/09/2021 Journal article Effectiveness of seasonal malaria chemoprevention treatments when SMC is implemented at scale This study found that SMC was highly effective in preventing clinical malaria when delivered at scale through national malaria control programmes. 08/09/2021 This study found that SMC was highly effective in preventing clinical malaria when delivered at scale through national malaria control programmes.
07/09/2021 Journal article Field efficacy of larvivorous fish and pyriproxyfen combined with community engagement on dengue vectors in Cambodia This trial aimed to demonstrate the community effectiveness of guppies, PPF and COMBI activities in reducing numbers of Aedes mosquitoes. 07/09/2021 This trial aimed to demonstrate the community effectiveness of guppies, PPF and COMBI activities in reducing numbers of Aedes mosquitoes.
19/08/2021 Journal article Knowledge assessment of anti-snake venom among healthcare practitioners in northern Nigeria Knowledge of anti-snake venom among healthcare practitioners is essential for achieving optimal clinical outcomes in snakebite management. 19/08/2021 Knowledge of anti-snake venom among healthcare practitioners is essential for achieving optimal clinical outcomes in snakebite management.
10/08/2021 Journal article An assessment of the knowledge, practices and resources during the delivery of malaria healthcare services among private healthcare practitioners This study determined the proportion of health workers in Uganda that adequately provided malaria case management according to national standards. 10/08/2021 This study determined the proportion of health workers in Uganda that adequately provided malaria case management according to national standards.
05/08/2021 Journal article Evaluating the feasibility and acceptability of a community dialogue intervention in the prevention and control of schistosomiasis in Nampula province, Mozambique This study aimed to test the community dialogue approach to improve schistosomiasis prevention and control in Nampula province. 05/08/2021 This study aimed to test the community dialogue approach to improve schistosomiasis prevention and control in Nampula province.
23/07/2021 Journal article Performance of five pulse oximeters to detect hypoxaemia as an indicator of severe illness in children under five by frontline health workers in low-resource settings In this first trial in Cambodia, Ethiopia, South Sudan and Uganda, researchers wanted to identify the most user-friendly pulse oximeters for frontline health workers. 23/07/2021 In this first trial in Cambodia, Ethiopia, South Sudan and Uganda, researchers wanted to identify the most user-friendly pulse oximeters for frontline health workers.
22/07/2021 Journal article The role of adaptive surveillance as a core intervention to achieve malaria elimination A strong surveillance system is critical to implementing an efficient and effective malaria programme to accelerate progress towards malaria elimination. 22/07/2021 A strong surveillance system is critical to implementing an efficient and effective malaria programme to accelerate progress towards malaria elimination.
02/07/2021 Journal article The effect of cattle-administered ivermectin and fipronil on the mortality and fecundity of Anopheles arabiensis Patton This study investigated the effect of two endectocides — injectable ivermectin and topical fipronil — on the survival and fecundity of zoophilic Anopheles arabiensis. 02/07/2021 This study investigated the effect of two endectocides — injectable ivermectin and topical fipronil — on the survival and fecundity of zoophilic Anopheles arabiensis.
26/06/2021 Journal article Aedes species (Diptera: Culicidae) ecological and host feeding patterns in the north-eastern parts of South Africa, 2014–2018 This study used entomological surveillance in selected areas to assess mosquito diversity, with special emphasis on the Aedes species. 26/06/2021 This study used entomological surveillance in selected areas to assess mosquito diversity, with special emphasis on the Aedes species.
13/06/2021 Journal article Evaluating the interrater agreement and acceptability of a new reference tool for assessing respiratory rate in children under five with cough and/or difficulty breathing A new reference tool which facilitates manual annotation of breaths based on videos was developed to improve diagnosis of suspected cases and appropriate treatment. 13/06/2021 A new reference tool which facilitates manual annotation of breaths based on videos was developed to improve diagnosis of suspected cases and appropriate treatment.
09/06/2021 Journal article Prevalence and seroprevalence of Plasmodium infection in Myanmar reveals highly heterogeneous transmission and a large hidden reservoir of infection The results of the first ever Myanmar Malaria Indicator Survey reveal programmatically important epidemiological findings not apparent in routine surveillance data. 09/06/2021 The results of the first ever Myanmar Malaria Indicator Survey reveal programmatically important epidemiological findings not apparent in routine surveillance data.
09/06/2021 Journal article Forced-egg laying method to establish F1 progeny from field populations and laboratory strains of Anopheles mosquitoes (Diptera: Culicidae) in Thailand This study explored the feasibility of using the forced-egg laying method for producing F1 from seven Anopheles species. 09/06/2021 This study explored the feasibility of using the forced-egg laying method for producing F1 from seven Anopheles species.
07/06/2021 Journal article Reactive, self-administered malaria treatment against asymptomatic malaria infection In the Gambia, this study co-developed and tested a trans-disciplinary approach to reduce prevalence in participating communities. 07/06/2021 In the Gambia, this study co-developed and tested a trans-disciplinary approach to reduce prevalence in participating communities.
29/05/2021 Journal article Report of the 2018 annual meeting of the Asia Pacific Malaria Elimination Network Vector Control Working Group The annual meeting took place 3–5 September 2018 in Bangkok, Thailand. Highlights from the meeting are described in this report. 29/05/2021 The annual meeting took place 3–5 September 2018 in Bangkok, Thailand. Highlights from the meeting are described in this report.
24/05/2021 Journal article The impact of malaria coinfection on Ebola virus disease outcomes: A systematic review and meta-analysis This study aims to understand how the malaria and Ebola virus interact which is important to establish for future outbreaks. 24/05/2021 This study aims to understand how the malaria and Ebola virus interact which is important to establish for future outbreaks.
13/05/2021 Journal article Navigating the COVID-19 crisis to sustain community-based malaria interventions in Cambodia We were able to provide continued support to mobile malaria workers and communities by conducting a COVID-19 rapid risk assessment and mitigation plan. 13/05/2021 We were able to provide continued support to mobile malaria workers and communities by conducting a COVID-19 rapid risk assessment and mitigation plan.
27/04/2021 Journal article Residual malaria transmission in select countries of Asia-Pacific region: Old wine in a new barrel Malaria persists with a disproportionate impact in the Asia-Pacific region. This systematic review looks at when and where residual malaria transmission is occurring. 27/04/2021 Malaria persists with a disproportionate impact in the Asia-Pacific region. This systematic review looks at when and where residual malaria transmission is occurring.
31/03/2021 Journal article Private healthcare market shaping and changes in inequities in childhood diarrhoea treatment coverage This study aims to examine inequities in the coverage of effective oral treatments for diarrhoea in under-fives in Nigeria. 31/03/2021 This study aims to examine inequities in the coverage of effective oral treatments for diarrhoea in under-fives in Nigeria.
26/03/2021 Journal article Health and demographic surveillance system: A potential tool for solving challenges associated with epidemic surveillance and social protection scheme for COVID-19 pandemic response in Nigeria A health and demographic surveillance system has the potential to strengthen the coping strategies of citizens in the face of the COVID-19 pandemic. 26/03/2021 A health and demographic surveillance system has the potential to strengthen the coping strategies of citizens in the face of the COVID-19 pandemic.
01/03/2021 Journal article Does integrated community case management target health inequities and treatment delays? Evidence from an analysis of demographic and health surveys data from 21 countries in the period 2010 to 2018 This research compares the contribution community health workers are making to healthcare provision with other healthcare providers. 01/03/2021 This research compares the contribution community health workers are making to healthcare provision with other healthcare providers.
25/02/2021 Journal article Antibiotic practices among household members and their domestic animals within rural communities in Cumilla district, Bangladesh This survey highlights the need for context-adapted interventions to reduce inappropriate antibiotic use among humans and domestic animals in rural Bangladesh. 25/02/2021 This survey highlights the need for context-adapted interventions to reduce inappropriate antibiotic use among humans and domestic animals in rural Bangladesh.
25/02/2021 Journal article Geographical and temporal variation in reduction of malaria infection among children under five years of age throughout Nigeria Between 2010 and 2018, there were significant declines in prevalence in 25 of the states, most pronounced in the southern and north-central zones of the country. 25/02/2021 Between 2010 and 2018, there were significant declines in prevalence in 25 of the states, most pronounced in the southern and north-central zones of the country.
22/02/2021 Journal article Eliminating Plasmodium falciparum malaria: Results from tailoring active case detection approaches to remote populations in forested border areas in north-eastern Cambodia This case study presents a successful approach to implementing tailored active case detection strategies in forested border areas in north-eastern Cambodia. 22/02/2021 This case study presents a successful approach to implementing tailored active case detection strategies in forested border areas in north-eastern Cambodia.
10/02/2021 Journal article Community health worker knowledge, attitudes and practices towards COVID-19: Learnings from an online cross-sectional survey using a digital health platform, UpSCALE, in Mozambique Adapting the existing upSCALE platform enabled a better understanding of community health workers' knowledge around COVID-19 management. 10/02/2021 Adapting the existing upSCALE platform enabled a better understanding of community health workers' knowledge around COVID-19 management.
29/01/2021 Journal article Seasonal malaria chemoprevention in the Sahel subregion of Africa: A cost-effectiveness and cost-savings analysis This study provides timely and important evidence on the cost, cost-effectiveness and potential cost savings of the first large-scale, multi-country SMC campaign. 29/01/2021 This study provides timely and important evidence on the cost, cost-effectiveness and potential cost savings of the first large-scale, multi-country SMC campaign.
29/01/2021 Journal article The burden of drug abuse in Nigeria: A scoping review of epidemiological studies and drug laws In this review, we summarise the recent data on drug abuse in Nigeria where drug abuse is on the rise and becoming a public health concern. 29/01/2021 In this review, we summarise the recent data on drug abuse in Nigeria where drug abuse is on the rise and becoming a public health concern.
19/01/2021 Journal article Assessment of COVID-19 information overload among the general public This assessment sought to measure the level of COVID-19 information overload and assess the sociodemographic characteristics among the public. 19/01/2021 This assessment sought to measure the level of COVID-19 information overload and assess the sociodemographic characteristics among the public.
09/01/2021 Journal article Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: A systematic review and meta-analysis (1998–2020) This review determines the prevalence and distribution of Plasmodium falciparum medicine resistance markers within an evolving efficacy of anti-malarial medicines. 09/01/2021 This review determines the prevalence and distribution of Plasmodium falciparum medicine resistance markers within an evolving efficacy of anti-malarial medicines.
09/01/2021 Journal article New assessment of Anopheles vector species identification using MALDI-TOF MS To determine the body part of Anopheles mosquitoes best suited for the identification of field specimens, a mass spectral library was generated. 09/01/2021 To determine the body part of Anopheles mosquitoes best suited for the identification of field specimens, a mass spectral library was generated.
07/01/2021 Journal article Challenges and strategies for conducting clinical research during the COVID-19 pandemic: Experiences from resource-limited settings We initiated an observational case series study to assess the magnitude and clinical consequences of coinfection of COVID-19, malaria and other common infections. 07/01/2021 We initiated an observational case series study to assess the magnitude and clinical consequences of coinfection of COVID-19, malaria and other common infections.
14/12/2020 Journal article COVID-19 knowledge, beliefs, prevention behaviours and misinformation in the context of an adapted seasonal malaria chemoprevention campaign in six northern Nigerian states In response to the global COVID-19 pandemic, we adapted our SMC delivery model to ensure safety of distributors, data collectors and communities. 14/12/2020 In response to the global COVID-19 pandemic, we adapted our SMC delivery model to ensure safety of distributors, data collectors and communities.
05/12/2020 Journal article Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: An observational study This study evaluates the ACCESS-SMC project, which sought to remove barriers to SMC scale-up in seven countries in 2015–2016. 05/12/2020 This study evaluates the ACCESS-SMC project, which sought to remove barriers to SMC scale-up in seven countries in 2015–2016.
17/06/2020 Journal article A process for developing a sustainable and scalable approach to community engagement: Community dialogue approach for addressing the drivers of antibiotic resistance in Bangladesh Taking the global challenge of antibiotic resistance as an example, this study explores the process of developing an embedded approach to community engagement. 17/06/2020 Taking the global challenge of antibiotic resistance as an example, this study explores the process of developing an embedded approach to community engagement.
26/05/2020 Journal article Protecting children in low-income and middle-income countries from COVID-19 Drawing on our shared child pneumonia experience globally, we highlight the potential impacts of COVID-19 on children and propose a collective response. 26/05/2020 Drawing on our shared child pneumonia experience globally, we highlight the potential impacts of COVID-19 on children and propose a collective response.
14/05/2020 Journal article Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systemic review and meta-analysis Our findings indicate that there is substantial variation in G6PD measurements by spectrophotometry between sites. 14/05/2020 Our findings indicate that there is substantial variation in G6PD measurements by spectrophotometry between sites.
06/04/2020 Journal article Community engagement interventions for communicable disease control in low- and lower- middle-income countries: Evidence from a review of systematic reviews Community engagement interventions may be effective in supporting communicable disease control in low and lower-middle income countries. 06/04/2020 Community engagement interventions may be effective in supporting communicable disease control in low and lower-middle income countries.
02/04/2020 Journal article Determining the agreement between an automated respiratory rate counter and a reference standard for detecting symptoms of pneumonia in children Correctly counting breaths manually and classifying the respiratory rate is challenging, often leading to inappropriate treatment. 02/04/2020 Correctly counting breaths manually and classifying the respiratory rate is challenging, often leading to inappropriate treatment.
30/03/2020 Journal article Automated respiratory rate counter to assess children for symptoms of pneumonia This is the first time the usability and acceptability of automated respiratory rate counters in low-resource settings have been evaluated. 30/03/2020 This is the first time the usability and acceptability of automated respiratory rate counters in low-resource settings have been evaluated.
27/02/2020 Journal article Evaluation of a capacity building intervention on malaria treatment for under‑fives in rural health facilities in Niger state, Nigeria This study assessed the effect on malaria diagnosis and prescription practices among febrile under-fives in rural health facilities. 27/02/2020 This study assessed the effect on malaria diagnosis and prescription practices among febrile under-fives in rural health facilities.
12/01/2020 Journal article Usability and acceptability of an automated respiratory rate counter to assess childhood pneumonia in Nepal We evaluated the usability of a new automated respiratory rate counter for female community health volunteers and caregivers in Nepal. 12/01/2020 We evaluated the usability of a new automated respiratory rate counter for female community health volunteers and caregivers in Nepal.
17/12/2019 Journal article Usability and acceptability of an automated respiratory rate counter to assess children for symptoms of pneumonia This study aimed to determine the usability and acceptability of a new automated respiratory rate counter by health extension workers in Ethiopia. 17/12/2019 This study aimed to determine the usability and acceptability of a new automated respiratory rate counter by health extension workers in Ethiopia.
17/12/2019 Journal article Implementation of guppy fish (Poecilia reticulata), and a novel larvicide (Pyriproxyfen) product (Sumilarv 2MR) for dengue control in Cambodia This study looks at community perceptions of biological controls to overcome insecticide resistance, for consideration in dengue control strategies. 17/12/2019 This study looks at community perceptions of biological controls to overcome insecticide resistance, for consideration in dengue control strategies.
13/12/2019 Journal article Gender-related factors affecting health seeking for neglected tropical diseases: Findings from a qualitative study in Ethiopia This study applied a gender lens to health-seeking in Ethiopia for five neglected tropical diseases. 13/12/2019 This study applied a gender lens to health-seeking in Ethiopia for five neglected tropical diseases.
05/12/2019 Journal article More work needs to be done to ensure that better pneumonia diagnostics aids are developed and launched to better support frontline health workers Malaria Consortium's response to Ansermino et al.'s article 'Are respiratory rate counters really so bad' was published in EClinicalMedicine. 05/12/2019 Malaria Consortium's response to Ansermino et al.'s article 'Are respiratory rate counters really so bad' was published in EClinicalMedicine.
18/11/2019 Journal article Consequences of restricting antimalarial drugs to rapid diagnostic test-positive febrile children in south-west Nigeria Objectives To investigate the consequence of restricting antimalarial treatment to febrile children that test positive to a malaria rapid diagnostic test (mRDT) only in an area of intense malaria transmission. Methods… 18/11/2019 Objectives To investigate the consequence of restricting antimalarial treatment to febrile children that test positive to a malaria rapid diagnostic test (mRDT) only in an area of intense malaria transmission. Methods Febrile children aged 3–59 months were screened with an mRDT…
07/11/2019 Journal article Institutionalisation of integrated community case management into national health systems in low- and middle-income countries: A scoping review of the literature Background Integrated community case management (iCCM) for malaria, pneumonia and diarrhoea continues to be a recommended strategy to address child mortality in areas where access to health facilities is limited. Objective To identify… 07/11/2019 Background Integrated community case management (iCCM) for malaria, pneumonia and diarrhoea continues to be a recommended strategy to address child mortality in areas where access to health facilities is limited. Objective To identify models of, and gaps in, institutionalisation of benchmark components of…
23/09/2019 Journal article Characterising residual malaria transmission in forested areas with low coverage of core vector control in central Viet Nam Background Despite great success in significantly reducing the malaria burden in Viet Nam over recent years, the ongoing presence of malaria vectors and Plasmodium infection in remote forest areas and among… 23/09/2019 Background Despite great success in significantly reducing the malaria burden in Viet Nam over recent years, the ongoing presence of malaria vectors and Plasmodium infection in remote forest areas and among marginalised groups presents a challenge to reaching elimination and a…
05/07/2019 Journal article Transmission risk beyond the village: entomological and human factors contributing to residual malaria transmission in an area approaching malaria elimination on the Thailand–Myanmar border Background A mixed methods study was conducted to look at the magnitude of residual malaria transmission (RMT) and factors contributing to low (< 1% prevalence), but sustained transmission in rural… 05/07/2019 Background A mixed methods study was conducted to look at the magnitude of residual malaria transmission (RMT) and factors contributing to low (< 1% prevalence), but sustained transmission in rural communities on the Thai–Myanmar border. Methods A cross-sectional behaviour and…
01/07/2019 Journal article Performance of four respiratory rate counters to support community health workers to detect the symptoms of pneumonia in children in low resource settings: A prospective, multicentre, hospital-based, single-blinded, comparative trial Background Pneumonia is one of the leading causes of death in children under-five globally. The current diagnostic criteria for pneumonia are based on increased respiratory rate (RR) or chest in-drawing in… 01/07/2019 Background Pneumonia is one of the leading causes of death in children under-five globally. The current diagnostic criteria for pneumonia are based on increased respiratory rate (RR) or chest in-drawing in children with cough and/or difficulty breathing. Accurately counting RR is…
27/06/2019 Journal article Effect of community-based intervention on improving access to treatment for sick under-five children in hard-to-reach communities in Niger State, Nigeria Background Access to prompt and appropriate treatment is key to survival for children with malaria, pneumonia and diarrhoea. Community-based services are vital to extending care to remote populations. Malaria Consortium supported… 27/06/2019 Background Access to prompt and appropriate treatment is key to survival for children with malaria, pneumonia and diarrhoea. Community-based services are vital to extending care to remote populations. Malaria Consortium supported Niger state Ministry of Health, Nigeria, to introduce and implement…
27/06/2019 Journal article Barriers on the pathway to survival for children dying from treatable illnesses in Inhambane province, Mozambique Background Mozambique has one of the highest under-5 mortality rates in the world. Community health workers (CHWs) are deployed to increase access to care; in Mozambique they are known as… 27/06/2019 Background Mozambique has one of the highest under-5 mortality rates in the world. Community health workers (CHWs) are deployed to increase access to care; in Mozambique they are known as agentes polivalentes elementares (APEs). This study aimed to investigate child…
27/06/2019 Journal article Community engagement and mobilisation of local resources to support integrated Community Case Management of childhood illnesses in Niger State, Nigeria This study wanted to document the process and scale achieved for community engagement and mobilisation to foster ownership and sustainability. 27/06/2019 This study wanted to document the process and scale achieved for community engagement and mobilisation to foster ownership and sustainability.
25/06/2019 Journal article Integrated community case management: Planning for sustainability in five African countries The World Health Organization launched an initiative to plan for the sustainability of integrated community case management (iCCM) programmes supported by the Rapid Access Expansion programme in five African countries… 25/06/2019 The World Health Organization launched an initiative to plan for the sustainability of integrated community case management (iCCM) programmes supported by the Rapid Access Expansion programme in five African countries in 2016.
10/03/2019 Journal article Dengue situation in Bangladesh: An epidemiological shift in terms of morbidity and mortality In this study, climatic changes and rapid unplanned urbanization were strong predictors of an ecological imbalance that led to increased dengue cases in 2016, and the emergence of chikungunya virus… 10/03/2019 In this study, climatic changes and rapid unplanned urbanization were strong predictors of an ecological imbalance that led to increased dengue cases in 2016, and the emergence of chikungunya virus in Bangladesh in 2017.
08/02/2019 Journal article Knowledge, attitudes and practices with regard to schistosomiasis prevention and control: Two cross-sectional household surveys before and after a community dialogue intervention in Nampula province, Mozambique Schistosomiasis is a parasitic neglected tropical disease that affects around 190 million people worldwide, causing chronic ill health and disability. Central to its prevention and control are the acceptance of… 08/02/2019 Schistosomiasis is a parasitic neglected tropical disease that affects around 190 million people worldwide, causing chronic ill health and disability. Central to its prevention and control are the acceptance of health interventions, such as mass drug distribution and the adoption…
12/11/2018 Journal article Comparative efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Ugandan children In Uganda, artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DHA-PQ) showed excellent treatment efficacy for uncomplicated malaria in prior trials. Because resistance to artemisinins and piperaquine is increasing in southeast Asia and the… 12/11/2018 In Uganda, artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DHA-PQ) showed excellent treatment efficacy for uncomplicated malaria in prior trials. Because resistance to artemisinins and piperaquine is increasing in southeast Asia and the prevalence of Plasmodium falciparum polymorphisms associated with resistance has changed,…
06/11/2018 Journal article Immediate assessment of performance of medical laboratory scientists following a 10-day malaria microscopy training programme in Nigeria Background Rapid and precise diagnosis of malaria is an essential element in effective case management and control of malaria. Malaria microscopy is used as the gold standard for malaria diagnosis, however… 06/11/2018 Background Rapid and precise diagnosis of malaria is an essential element in effective case management and control of malaria. Malaria microscopy is used as the gold standard for malaria diagnosis, however results remain poor as positivity rate in Nigeria is consistently…
26/10/2018 Journal article Effect of environmental variables and kdr resistance genotype on survival probability and infection rates in Anopheles gambiae (s.s) BACKGROUND: Environmental factors, especially ambient temperature and relative humidity affect both mosquitoes and malaria parasites. The early part of sporogony is most sensitive and is affected by high temperatures and temperature… 26/10/2018 BACKGROUND: Environmental factors, especially ambient temperature and relative humidity affect both mosquitoes and malaria parasites. The early part of sporogony is most sensitive and is affected by high temperatures and temperature fluctuation immediately following ingestion of an infectious blood meal. The…
25/10/2018 Journal article Performance, Acceptability, and Usability of Respiratory Rate Timers and Pulse Oximeters When Used by Frontline Health Workers to Detect Symptoms of Pneumonia in Sub-Saharan Africa and Southeast Asia: Protocol for a Two-Phase, Multisite, Mixed-Methods Trial BACKGROUND:Pneumonia is one of the leading causes of death in children aged under 5 years in both sub-Saharan Africa and Southeast Asia. The current diagnostic criterion for pneumonia is based… 25/10/2018 BACKGROUND:Pneumonia is one of the leading causes of death in children aged under 5 years in both sub-Saharan Africa and Southeast Asia. The current diagnostic criterion for pneumonia is based on the increased respiratory rate (RR) in children with cough…
10/10/2018 Journal article Digital Technologies for Health Workforce Development in Low- and Middle-Income Countries: A Scoping Review The collection of journal articles, systematic reviews, and reports published over the last decade that attest to the potential of digital technologies to achieve health workforce improvements across all aspects… 10/10/2018 The collection of journal articles, systematic reviews, and reports published over the last decade that attest to the potential of digital technologies to achieve health workforce improvements across all aspects of the health system is vast. As a capacity-building mechanism,…
17/09/2018 Journal article Management and Follow-up Practices of Children with Unclassified Fever in Rural Ethiopia: Experiences of Health Extension Workers and Caregivers Different health-care management guidelines by the World Health Organization exist to help health workers in resource-limited settings treat patients. However, for children with unclassified fever and no danger signs, management… 17/09/2018 Different health-care management guidelines by the World Health Organization exist to help health workers in resource-limited settings treat patients. However, for children with unclassified fever and no danger signs, management guidelines are less clear and follow-up recommendations differ. Both a…
06/09/2018 Journal article Improving health worker performance through text messaging: A mixed-methods evaluation of a pilot intervention designed to increase coverage of intermittent preventive treatment of malaria in pregnancy in West Nile, Uganda Poor health worker performance is a well-documented obstacle to quality service provision. Due to the increasingly widespread availability of mobile devices, mobile health (mHealth) has received growing attention as a… 06/09/2018 Poor health worker performance is a well-documented obstacle to quality service provision. Due to the increasingly widespread availability of mobile devices, mobile health (mHealth) has received growing attention as a service improvement tool. This pilot study explored feasibility, acceptability and…
17/08/2018 Journal article Human and Simian Malaria in the Greater Mekong Subregion and Challenges for Elimination In recent years malaria initiatives have increasingly shifted from malaria control to a focus on achieving malaria elimination in the Southeast Asia region. However, this region experiences unique challenges in… 17/08/2018 In recent years malaria initiatives have increasingly shifted from malaria control to a focus on achieving malaria elimination in the Southeast Asia region. However, this region experiences unique challenges in this transition due to its distinctive malariaecosystem (mainly related to…
19/07/2018 Journal article Community understanding of the concept of pre-referral treatment and how this impacts on referral related decision-making following the provision of rectal artesunate: A qualitative study in western Uganda Background Successful pre-referral treatment with rectal artesunate (RA) for suspected severe malaria requires operational linkages between community health workers (CHWs) and referral facilities, acceptance of pre-referral treatment and adherence to referral… 19/07/2018 Background Successful pre-referral treatment with rectal artesunate (RA) for suspected severe malaria requires operational linkages between community health workers (CHWs) and referral facilities, acceptance of pre-referral treatment and adherence to referral practices by CHWs and caregivers. This qualitative study investigated how…
29/06/2018 Journal article Design, Implementation, and Evaluation of a School Insecticide-Treated Net Distribution Program in Cross River State, Nigeria Background: In 2013, the World Health Organization recommended distribution through schools, health facilities, community health workers, and mass campaigns to maintain coverage with insecticide-treated nets (ITNs). We piloted school distribution in… 29/06/2018 Background: In 2013, the World Health Organization recommended distribution through schools, health facilities, community health workers, and mass campaigns to maintain coverage with insecticide-treated nets (ITNs). We piloted school distribution in 3 local government areas (LGAs) of Cross River State, Nigeria. Methods: From…
12/04/2018 Journal article Universal versus conditional third day follow-up visit for children with nonsevere unclassified fever at the community level in Ethiopia: Protocol for a cluster randomized noninferiority trial BackgroundUnder the World Health Organization’s integrated community case management strategy, febrile children seen by community health workers (on day one) without a diagnosable illness and without danger signs are advised… 12/04/2018 BackgroundUnder the World Health Organization’s integrated community case management strategy, febrile children seen by community health workers (on day one) without a diagnosable illness and without danger signs are advised to return on day three, regardless of symptom resolution. This…
22/03/2018 Journal article Impact of a 15-month multi-channel continuous distribution pilot on ITN ownership and access in Eastern Region, Ghana Background: Insecticide-treated nets are a key intervention for malaria prevention. While mass distribution can rapidly scale up ITN coverage, multiple channels may be needed to sustain high levels of ITN access… 22/03/2018 Background: Insecticide-treated nets are a key intervention for malaria prevention. While mass distribution can rapidly scale up ITN coverage, multiple channels may be needed to sustain high levels of ITN access and ownership. In Ghana's Eastern Region, a continuous ITN distribution…
14/03/2018 Journal article Resistance of Aedes aegypti (Diptera: Culicidae) Populations to Deltamethrin, Permethrin, and Temephos in Cambodia Background Dengue fever is a major public health issue in Cambodia, with over 185,000 cases estimated annually. Transmission occurs primarily through the Aedis aegypti vector, which favours environments where water storage… 14/03/2018 Background Dengue fever is a major public health issue in Cambodia, with over 185,000 cases estimated annually. Transmission occurs primarily through the Aedis aegypti vector, which favours environments where water storage is abundant and solid waste disposal is deficient. This vector…
16/02/2018 Journal article Dengue knowledge, attitudes and practices and their impact on community-based vector control in rural Cambodia BackgroundGlobally there are an estimated 390 million dengue infections per year, of which 96 million are clinically apparent. In Cambodia, estimates suggest as many as 185,850 cases annually. The World… 16/02/2018 BackgroundGlobally there are an estimated 390 million dengue infections per year, of which 96 million are clinically apparent. In Cambodia, estimates suggest as many as 185,850 cases annually. The World Health Organization global strategy for dengue prevention aims to reduce…
06/02/2018 Journal article Private sector malaria RDT initiative in Nigeria: lessons from an end-of-project stakeholder engagement meeting BackgroundThe malaria rapid diagnosis testing (RDT) landscape is rapidly evolving in health care delivery in Nigeria with many stakeholders playing or having potential for critical roles. A recent UNITAID grant… 06/02/2018 BackgroundThe malaria rapid diagnosis testing (RDT) landscape is rapidly evolving in health care delivery in Nigeria with many stakeholders playing or having potential for critical roles. A recent UNITAID grant supported a pilot project on the deployment of quality-assured RDTs…
06/01/2018 Journal article Immediate assessment of performance of medical laboratory scientists following a 10-day malaria microscopy training programme in Nigeria Background Rapid and precise diagnosis of malaria is an essential element in effective case management and control of malaria. Malaria microscopy is used as the gold standard for malaria diagnosis, however,… 06/01/2018 Background Rapid and precise diagnosis of malaria is an essential element in effective case management and control of malaria. Malaria microscopy is used as the gold standard for malaria diagnosis, however, results remain poor as positivity rate in Nigeria is consistently…
28/11/2017 Journal article Integrated community case management in a peri-urban setting: A qualitative evaluation in Wakiso District, Uganda Background Integrated community case management (iCCM) strategies aim to reach poor communities by providing timely access to treatment for malaria, pneumonia and diarrhoea for children under 5 years of age.… 28/11/2017 Background Integrated community case management (iCCM) strategies aim to reach poor communities by providing timely access to treatment for malaria, pneumonia and diarrhoea for children under 5 years of age. Community health workers, known as Village Health Teams (VHTs) in…
23/11/2017 Journal article Spatiotemporal distribution and population at risk of soil-transmitted helminth infections following an eight-year school-based deworming programme in Burundi, 2007-2014. Background Investigating the effect of successive annual deworming rounds on the spatiotemporal distribution of infection prevalence and numbers at risk for soil-transmitted helminths (STHs) can help identify communities nearing elimination and… 23/11/2017 Background Investigating the effect of successive annual deworming rounds on the spatiotemporal distribution of infection prevalence and numbers at risk for soil-transmitted helminths (STHs) can help identify communities nearing elimination and those needing further interventions. In this study, we aim to…
09/10/2017 Journal article Neglected tropical diseases: Exploring long-term practical approaches to achieve sustainable disease elimination and beyond This paper identifies two major priorities in the fight against NTDs: strengthening the capacity of the primary health care health system in correctly diagnosing and managing such diseases, and establishing an effective… 09/10/2017 This paper identifies two major priorities in the fight against NTDs: strengthening the capacity of the primary health care health system in correctly diagnosing and managing such diseases, and establishing an effective disease surveillance process.
17/08/2017 Journal article Evaluation of a continuous community-based insecticide-treated nets distribution pilot in Lainya County, South Sudan 2012–2013 Background Continuous distribution of insecticide-treated nets (ITNs) has now been accepted as one way of sustaining ITN universal coverage. Community-based channels offer an interesting means of delivering ITNs to households to… 17/08/2017 Background Continuous distribution of insecticide-treated nets (ITNs) has now been accepted as one way of sustaining ITN universal coverage. Community-based channels offer an interesting means of delivering ITNs to households to sustain universal ITN coverage. The objective of this study was…
10/08/2017 Journal article Evaluation of community-based continuous distribution of long lasting insecticide-treated nets in Toamasina II District, Madagascar Background Continuous distribution of insecticide-treated nets (ITNs) is thought to be an effective mechanism to maintain ITN ownership and access between or in the absence of mass campaigns, but evidence is… 10/08/2017 Background Continuous distribution of insecticide-treated nets (ITNs) is thought to be an effective mechanism to maintain ITN ownership and access between or in the absence of mass campaigns, but evidence is limited. A community-based ITN distribution pilot was implemented and evaluated…
07/08/2017 Journal article Determining the efficacy of guppies and pyriproxyfen (Sumilarv® 2MR) combined with community engagement on dengue vectors in Cambodia: Study protocol for a randomised controlled trial Background Evidence on the effectiveness of low-cost, sustainable, biological vector-control tools for the Aedes mosquitoes is limited. Therefore, the purpose of this trial is to estimate the impact of guppy fish… 07/08/2017 Background Evidence on the effectiveness of low-cost, sustainable, biological vector-control tools for the Aedes mosquitoes is limited. Therefore, the purpose of this trial is to estimate the impact of guppy fish (guppies), in combination with the use of the larvicide pyriproxyfen…
06/07/2017 Journal article Mass drug administration in Central Equatoria, South Sudan: Results and suggestions for future distributions Background South Sudan has rolled out a neglected tropical disease programme, which envisaged deworming campaigns in states endemic for soil transmitted helminth infections and schistosomiasis. Methods In 2016, two deworming campaigns targeting school-age… 06/07/2017 Background South Sudan has rolled out a neglected tropical disease programme, which envisaged deworming campaigns in states endemic for soil transmitted helminth infections and schistosomiasis. Methods In 2016, two deworming campaigns targeting school-age children were performed in Central Equatoria. Distribution sites were set…
14/06/2017 Journal article Experiences from developing and upgrading a web-based surveillance system for malaria elimination in Cambodia Abstract Strengthening the surveillance component is key toward achieving country-wide malaria elimination in Cambodia. A web-based upgraded malaria information system (MIS) was deemed to essentially act as the central component for… 14/06/2017 Abstract Strengthening the surveillance component is key toward achieving country-wide malaria elimination in Cambodia. A web-based upgraded malaria information system (MIS) was deemed to essentially act as the central component for surveillance strengthening. New functionality (eg, data visualization) and operational (eg,…
07/06/2017 Journal article Community dialogues for child health: Results from a qualitative process evaluation in three countries Background Across the developing world, countries are increasingly adop ting the integrated community casemanagement of childhood illnesses (iCCM) strategy in efforts to reduce child mortality. This intervention’s effectivenessis dependent on community… 07/06/2017 Background Across the developing world, countries are increasingly adop ting the integrated community casemanagement of childhood illnesses (iCCM) strategy in efforts to reduce child mortality. This intervention’s effectivenessis dependent on community adop tion and changes in care-seeking practices. We assessed the…
09/05/2017 Journal article Childhood pneumonia diagnostics: Community health workers’ and national stakeholders’ differing perspectives of new and existing aids Background Pneumonia heavily contributes to global under-five mortality. Many countries use community case management to detect and treat childhood pneumonia. Community health workers (CHWs) have limited tools to help them assess… 09/05/2017 Background Pneumonia heavily contributes to global under-five mortality. Many countries use community case management to detect and treat childhood pneumonia. Community health workers (CHWs) have limited tools to help them assess signs of pneumonia. New respiratory rate (RR) counting devices and…
20/04/2017 Journal article Insecticide resistance patterns in Uganda and the effect of indoor residual spraying with bendiocarb on kdr L1014S frequencies in Anopheles gambiae s.s. Background Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and the use of chemicals in agriculture. The… 20/04/2017 Background Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and the use of chemicals in agriculture. The use of different classes of insecticides in combination or by…
20/04/2017 Journal article Quality issues with malaria rapid diagnostic test accessories and buffer packaging: Findings from a five-country private sector project in Africa Background: Use of antigen-detecting malaria rapid diagnostic tests (RDTs) has increased exponentially over the last decade. WHO's Global Malaria Programme, FIND, and other collaborators have established a quality assurance scheme to… 20/04/2017 Background: Use of antigen-detecting malaria rapid diagnostic tests (RDTs) has increased exponentially over the last decade. WHO's Global Malaria Programme, FIND, and other collaborators have established a quality assurance scheme to guide product selection, lot verification, transport, storage, and training procedures.…
17/04/2017 Journal article Travel and the emergence of high-level drug resistance in Plasmodium falciparum in southwest Uganda: Results from a population-based study Background The I164L mutation on the dhfr gene confers high level resistance to sulfadoxine–pyrimethamine (SP) but it is rare in Africa except in a cluster of reports where prevalence >10%… 17/04/2017 Background The I164L mutation on the dhfr gene confers high level resistance to sulfadoxine–pyrimethamine (SP) but it is rare in Africa except in a cluster of reports where prevalence >10% in highland areas of southwest Uganda and eastern Rwanda. The…
28/03/2017 Journal article Acceptability of insecticide-treated clothing for malaria prevention among migrant rubber tappers in Myanmar: A cluster-randomised non-inferiority crossover trial Background Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary… 28/03/2017 Background Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary vector control measure, ITC could be used to address outdoor…
09/11/2016 Journal article Pneumococcal carriage in children under five years in Uganda: Will present pneumococcal conjugate vaccines be appropriate? Background Pneumonia is the major cause of death in children globally, with more than 900,000 deaths annually in children under five years of age. Streptococcus pneumoniae causes most deaths, most often… 09/11/2016 Background Pneumonia is the major cause of death in children globally, with more than 900,000 deaths annually in children under five years of age. Streptococcus pneumoniae causes most deaths, most often in the form of community acquired pneumonia. Pneumococcal conjugate vaccines…
04/11/2016 Journal article Assessing demand-side barriers to uptake of intermittent preventive treatment for malaria in pregnancy: A qualitative study in two regions of Uganda Background To prevent malaria infection during pregnancy in endemic areas in Africa, the World Health Organization recommends the administration of intermittent preventive treatment in pregnancy (IPTp) as part of the focused… 04/11/2016 Background To prevent malaria infection during pregnancy in endemic areas in Africa, the World Health Organization recommends the administration of intermittent preventive treatment in pregnancy (IPTp) as part of the focused antenatal care package. However, IPTp uptake in most countries remains…
27/10/2016 Journal article An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia Background In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum… 27/10/2016 Background In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. The targeted group was…
18/10/2016 Journal article Health worker and policy-maker perspectives on use of intramuscular artesunate for pre-referral and definitive treatment of severe malaria at health posts in Ethiopia Background The World Health Organization (WHO) recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment for severe malaria and recommends a single intramuscular dose of… 18/10/2016 Background The World Health Organization (WHO) recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment for severe malaria and recommends a single intramuscular dose of intramuscular artesunate or intramuscular artemether or intramuscular quinine, in that…
12/10/2016 Journal article Health worker perspectives on the possible use of intramuscular artesunate for the treatment of severe malaria at lower-level health facilities in settings with poor access to referral facilities in Nigeria: a qualitative study Background Innovative strategies are needed to reduce malaria mortality in high burden countries like Nigeria. Given that one of the important reasons for this high malaria mortality is delay in receiving… 12/10/2016 Background Innovative strategies are needed to reduce malaria mortality in high burden countries like Nigeria. Given that one of the important reasons for this high malaria mortality is delay in receiving effective treatment, improved access to such treatment is critical. Intramuscular…
05/10/2016 Journal article Plasmodium vivax Malaria in Cambodia Background The Cambodian National Strategic Plan for Elimination of Malaria aims to move step by step toward elimination of malaria across Cambodia with an initial focus on Plasmodium falciparum malaria before… 05/10/2016 Background The Cambodian National Strategic Plan for Elimination of Malaria aims to move step by step toward elimination of malaria across Cambodia with an initial focus on Plasmodium falciparum malaria before achieving elimination of all forms of malaria, including Plasmodium vivax…
29/09/2016 Journal article Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V Background There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate reductase (dhfr) genes in P. falciparum populations in Nigeria, but one previous study has recorded a novel… 29/09/2016 Background There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate reductase (dhfr) genes in P. falciparum populations in Nigeria, but one previous study has recorded a novel dhps mutation at codon 431 among infections imported to the…
15/09/2016 Journal article The use of formative research to inform the design of a seasonal malaria chemoprevention intervention in northern Nigeria Background Experience of seasonal malaria chemoprevention (SMC) is growing in the Sahel sub-region of Africa, though there remains insufficient evidence to recommend a standard deployment strategy. In 2012, a project was… 15/09/2016 Background Experience of seasonal malaria chemoprevention (SMC) is growing in the Sahel sub-region of Africa, though there remains insufficient evidence to recommend a standard deployment strategy. In 2012, a project was initiated in Katsina state, northern Nigeria, to design an appropriate…
06/09/2016 Journal article National malaria prevalence in Cambodia: Microscopy versus polymerase chain reaction estimates Abstract Accurate information regarding malaria prevalence at national level is required to design and assess malaria control/elimination efforts. Although many comparisons of microscopy and polymerase chain reaction (PCR)-based methods have been… 06/09/2016 Abstract Accurate information regarding malaria prevalence at national level is required to design and assess malaria control/elimination efforts. Although many comparisons of microscopy and polymerase chain reaction (PCR)-based methods have been conducted, there is little published literature covering such comparisons in…
27/08/2016 Journal article Rational use of antibiotics by community health workers and caregivers for children with suspected pneumonia in Zambia: A cross-sectional mixed methods study Background Antibiotic resistance is an issue of growing global concern. One key strategy to minimise further development of resistance is the rational use of antibiotics, by providers and patients alike. Through… 27/08/2016 Background Antibiotic resistance is an issue of growing global concern. One key strategy to minimise further development of resistance is the rational use of antibiotics, by providers and patients alike. Through integrated community case management (iCCM), children diagnosed with suspected pneumonia…
04/07/2016 Journal article Assessing supply-side barriers to uptake of intermittent preventive treatment for malaria in pregnancy: A qualitative study and document and record review in two regions of Uganda Background Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine (SP), provided as part of routine antenatal care (ANC), is one of three malaria-in-pregnancy prevention and control mechanisms recommended by the World… 04/07/2016 Background Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine (SP), provided as part of routine antenatal care (ANC), is one of three malaria-in-pregnancy prevention and control mechanisms recommended by the World Health Organization (WHO). However, despite high ANC attendance and increased…
18/04/2016 Journal article Reactive case-detection of malaria in Pailin province, western Cambodia: Lessons from a year-long evaluation in a pre-elimination setting Background As momentum towards malaria elimination grows, strategies are being developed for scale-up in elimination settings. One prominent strategy, reactive case detection (RACD), involves screening and treating individuals living in close… 18/04/2016 Background As momentum towards malaria elimination grows, strategies are being developed for scale-up in elimination settings. One prominent strategy, reactive case detection (RACD), involves screening and treating individuals living in close proximity to passively detected, or “index” cases. This study aims…
31/03/2016 Journal article Assessing the quality of care for pneumonia in integrated community case management: A cross-sectional mixed methods study Background Pneumonia is the leading infectious cause of mortality in children under five worldwide. Community-level interventions, such as integrated community case management, have great potential to reduce the burden of pneumonia,… 31/03/2016 Background Pneumonia is the leading infectious cause of mortality in children under five worldwide. Community-level interventions, such as integrated community case management, have great potential to reduce the burden of pneumonia, as well as other diseases, especially in remote populations. However,…
31/03/2016 Journal article Have you heard of schistosomiasis? Knowledge, attitudes and practices in Nampula province, Mozambique Background Schistosomiasis is a parasitic disease which affects almost 300 million people worldwide each year. It is highly endemic in Mozambique. Prevention and control of schistosomiasis relies mainly on mass drug… 31/03/2016 Background Schistosomiasis is a parasitic disease which affects almost 300 million people worldwide each year. It is highly endemic in Mozambique. Prevention and control of schistosomiasis relies mainly on mass drug administration (MDA), as well as adoption of basic sanitation practices.…
26/02/2016 Journal article Exposure to deltamethrin affects development of Plasmodium falciparum inside wild pyrethroid resistant Anopheles gambiae s.s. mosquitoes in Uganda Background Pyrethroid resistance in African vector mosquitoes is a threat to malaria control. Resistant mosquitoes can survive insecticide doses that would normally be lethal. We studied effects of such doses on… 26/02/2016 Background Pyrethroid resistance in African vector mosquitoes is a threat to malaria control. Resistant mosquitoes can survive insecticide doses that would normally be lethal. We studied effects of such doses on Plasmodium falciparum development inside kdr-resistant Anopheles gambiae s.s. in Uganda. Methods We…
16/02/2016 Journal article Positive deviance as a novel tool in malaria control and elimination: methodology, qualitative assessment and future potential Background Positive deviance (PD) is an asset-based, community-driven approach to behaviour change that has successfully been applied to address many health and social problems. It is yet to have been assessed… 16/02/2016 Background Positive deviance (PD) is an asset-based, community-driven approach to behaviour change that has successfully been applied to address many health and social problems. It is yet to have been assessed for malaria control but may represent a promising tool for…
23/11/2015 Journal article Early identification and treatment of pneumonia: A call to action This call for action published by the Lancet Global Health on World Pneumonia Day 2015, calls for improved early identification and treatment of childhood pneumonia at community and outpatient level… 23/11/2015 This call for action published by the Lancet Global Health on World Pneumonia Day 2015, calls for improved early identification and treatment of childhood pneumonia at community and outpatient level to reduce deaths. Published in Lancet Global Health
02/10/2015 Journal article Impact of a behaviour change communication programme on net durability in eastern Uganda Background The importance of net durability and the average useful life of a net is increasingly recognized as one of the critical factors that determine how often nets need to be… 02/10/2015 Background The importance of net durability and the average useful life of a net is increasingly recognized as one of the critical factors that determine how often nets need to be replaced. A study to assess the effect of a net…
17/09/2015 Journal article Entomological surveillance following a long-lasting insecticidal net universal coverage campaign in Midwestern Uganda Background A universal coverage campaign (UCC) with long-lasting insecticidal nets (LLINs) was implemented in four districts in Midwestern Uganda in 2009–2010. Entomological surveys were carried out to monitor changes in vector… 17/09/2015 Background A universal coverage campaign (UCC) with long-lasting insecticidal nets (LLINs) was implemented in four districts in Midwestern Uganda in 2009–2010. Entomological surveys were carried out to monitor changes in vector density, behaviour and malaria transmission following this intervention. Methods Anopheles mosquitoes were…
09/09/2015 Journal article Novel cross-border approaches to optimise identification of asymptomatic and artemisinin-resistant plasmodium infection in mobile populations crossing Cambodian borders Background Human population movement across country borders presents a real challenge for malaria control and elimination efforts in Cambodia and its neighbouring countries. To quantifyPlasmodium infection among the border-crossing population, including… 09/09/2015 Background Human population movement across country borders presents a real challenge for malaria control and elimination efforts in Cambodia and its neighbouring countries. To quantifyPlasmodium infection among the border-crossing population, including asymptomatic and artemisinin resistant (AR) parasites, three official border crossing…
04/09/2015 Journal article Monitoring changes in malaria epidemiology and effectiveness of interventions in Ethiopia and Uganda: Beyond Garki Project baseline survey Scale-up of malaria interventions seems to have contributed to a decline in the disease, but other factors may be at play. Understanding changes in transmission and determinant factors will help… 04/09/2015 Scale-up of malaria interventions seems to have contributed to a decline in the disease, but other factors may be at play. Understanding changes in transmission and determinant factors will help to adapt control strategies accordingly.
04/09/2015 Journal article Impact of an integrated community case management programme on uptake of appropriate diarrhoea and pneumonia treatments in Uganda: A propensity score matching and equity analysis study IntroductionFollowing introduction of iCCM, data from cross-sectional household surveys were examined for socioeconomic inequalities in uptake of treatment and use of iCCM among children with a classification of pneumonia or… 04/09/2015 IntroductionFollowing introduction of iCCM, data from cross-sectional household surveys were examined for socioeconomic inequalities in uptake of treatment and use of iCCM among children with a classification of pneumonia or diarrhoea using the Erreygers’ corrected concentration index (CCI). Propensity score…
28/08/2015 Journal article Estimating the cost of referral and willingness to pay for referral to higher-level health facilities: a case series study from an integrated community case management programme in Uganda Background Integrated community case management relies on community health workers managing children with malaria, pneumonia, diarrhoea, and referring children when management is not possible. This study sought to establish the cost… 28/08/2015 Background Integrated community case management relies on community health workers managing children with malaria, pneumonia, diarrhoea, and referring children when management is not possible. This study sought to establish the cost per sick child referred to seek care from a higher-level…
25/08/2015 Journal article Evaluation of integrated community case management in eight districts of central Uganda Objective Evidence is limited on whether Integrated Community Case Management (iCCM) improves treatment coverage of the top causes of childhood mortality (acute respiratory illnesses (ARI), diarrhoea and malaria). The coverage impact… 25/08/2015 Objective Evidence is limited on whether Integrated Community Case Management (iCCM) improves treatment coverage of the top causes of childhood mortality (acute respiratory illnesses (ARI), diarrhoea and malaria). The coverage impact of iCCM in Central Uganda was evaluated. Methods Between July 2010 and…
25/08/2015 Journal article High prevalence of antibiotic resistance in nasopharyngeal bacterial isolates from healthy children in rural Uganda: A cross-sectional study Background In Uganda, the main causes of death in children under 5 years of age are malaria and pneumonia-often due to delayed diagnosis and treatment. In preparation for a community case… 25/08/2015 Background In Uganda, the main causes of death in children under 5 years of age are malaria and pneumonia-often due to delayed diagnosis and treatment. In preparation for a community case management intervention for pneumonia and malaria, the bacterial composition of…
03/07/2015 Journal article Malaria and the mobile and migrant population in Cambodia: A population movement framework to inform strategies for malaria control and elimination Background The relationships between human population movement (HPM) and health are a concern at global level. In the case of malaria, those links are crucial in relation to the spread of… 03/07/2015 Background The relationships between human population movement (HPM) and health are a concern at global level. In the case of malaria, those links are crucial in relation to the spread of drug resistant parasites and to the elimination of malaria in…
01/07/2015 Journal article Potential roles of mhealth for community health workers: Formative research with end users in Uganda and Mozambique Background Community health workers are reemerging as an essential component of health systems in low-income countries. However, there are concerns that unless they are adequately supported, their motivation and performance will… 01/07/2015 Background Community health workers are reemerging as an essential component of health systems in low-income countries. However, there are concerns that unless they are adequately supported, their motivation and performance will be suboptimal. mHealth presents an opportunity to improve support for…
22/05/2015 Journal article Valuing the work of unpaid community health workers and exploring the incentives to volunteering in rural Africa Abstract Community health worker (CHW) programmes are currently being scaled-up in sub-Saharan Africa to improve access to healthcare. CHWs are often volunteers; from an economic perspective, this raises considerations whether reliance… 22/05/2015 Abstract Community health worker (CHW) programmes are currently being scaled-up in sub-Saharan Africa to improve access to healthcare. CHWs are often volunteers; from an economic perspective, this raises considerations whether reliance on an unpaid workforce is sustainable and how to appropriately…
30/04/2015 Journal article Using theory and formative research to design interventions to improve community health worker motivation, retention and performance in Mozambique and Uganda Background Community health workers (CHWs) are increasingly being used in low-income countries to address human resources shortages, yet there remain few effective, evidence-based strategies for addressing the enduring programmatic constraints of… 30/04/2015 Background Community health workers (CHWs) are increasingly being used in low-income countries to address human resources shortages, yet there remain few effective, evidence-based strategies for addressing the enduring programmatic constraints of worker motivation, retention and performance. This paper describes how two…
12/04/2015 Journal article Evaluating the effect of innovative motivation and supervision approaches on community health worker performance and retention in Uganda and Mozambique: study protocol for a randomised controlled trial Background If trained, equipped and utilised, community health workers (CHWs) delivering integrated community case management for sick children can potentially reduce child deaths by 60%. However, it is essential to maintain… 12/04/2015 Background If trained, equipped and utilised, community health workers (CHWs) delivering integrated community case management for sick children can potentially reduce child deaths by 60%. However, it is essential to maintain CHW motivation and performance. The inSCALE project aims to evaluate,…
16/03/2015 Journal article The effect of single or repeated home visits on the hanging and use of insecticide-treated mosquito nets following a mass distribution campaign: A cluster randomized, controlled trial Background The study objective was to evaluate the effectiveness of commonly used post-campaign hang-up visits on the hanging and use of campaign nets. Methods A cluster-randomized trial was carried out in Uganda following… 16/03/2015 Background The study objective was to evaluate the effectiveness of commonly used post-campaign hang-up visits on the hanging and use of campaign nets. Methods A cluster-randomized trial was carried out in Uganda following an ITN distribution campaign. Five clusters (parishes, consisting of ∼11…
01/12/2014 Journal article Integrated community case management of malaria, pneumonia and diarrhoea across three African countries: A qualitative study exploring lessons learnt and implications for further scale up Abstract Numerous studies highlight the effectiveness of an integrated approach for the management of malaria, pneumonia and diarrhoea at the community level. There has however been little study on lessons… 01/12/2014 Abstract Numerous studies highlight the effectiveness of an integrated approach for the management of malaria, pneumonia and diarrhoea at the community level. There has however been little study on lessons learnt from implementation in practice and stakeholder experiences which could…
01/12/2014 Journal article Demand generation and social mobilisation for integrated community case management (iCCM) and child health: Lessons learned from successful programmes in Niger and Mozambique Aim We present the approaches used in and outcomes resulting from integrated community case management (iCCM) programmes in Niger and Mozambique with a strong focus on demand generation and social mobilisation. Methods We… 01/12/2014 Aim We present the approaches used in and outcomes resulting from integrated community case management (iCCM) programmes in Niger and Mozambique with a strong focus on demand generation and social mobilisation. Methods We use a case study approach to describe the programme and…
01/12/2014 Journal article A proposed model to conduct process and outcome evaluations and implementation research of child health programs in Africa using integrated community case management as an example This article co-authored by Malaria Consortium staff is published by the Journal of Global Health in a Decemeber 2014 special supplement on current scientific evidence and future directions for integrated… 01/12/2014 This article co-authored by Malaria Consortium staff is published by the Journal of Global Health in a Decemeber 2014 special supplement on current scientific evidence and future directions for integrated community case management in Africa. Aim To use a newly devised set…
27/11/2014 Journal article What happens to lost nets: A multi-country analysis of reasons for LLIN attrition using 14 household surveys in four countries Background While significant focus has been given to net distribution, little is known about what is done with nets that leave a household, either to be used by others or when… 27/11/2014 Background While significant focus has been given to net distribution, little is known about what is done with nets that leave a household, either to be used by others or when they are discarded. To better understand the magnitude of sharing…
11/11/2014 Journal article Multi–country analysis of routine data from integrated community case management (iCCM) programs in sub–Saharan Africa Aim To identify better performing iCCM programs in sub–Saharan Africa (SSA) and identify factors associated with better performance using routine data. Methods We examined 15 evaluations or studies of integrated community case management… 11/11/2014 Aim To identify better performing iCCM programs in sub–Saharan Africa (SSA) and identify factors associated with better performance using routine data. Methods We examined 15 evaluations or studies of integrated community case management (iCCM) programs in SSA conducted between 2008 and 2013 and…
14/10/2014 Journal article Routine monitoring systems for integrated community case management programs: Lessons from 18 countries in sub–Saharan Africa Abstract Integrated community case management (iCCM) programs are expanding rapidly in many low– and middle–income countries, particularly in sub–Saharan Africa. Conclusions from the recent review of iCCM programs in Africa emphasized… 14/10/2014 Abstract Integrated community case management (iCCM) programs are expanding rapidly in many low– and middle–income countries, particularly in sub–Saharan Africa. Conclusions from the recent review of iCCM programs in Africa emphasized the critical importance of using routine data to assess program…
10/10/2014 Journal article Setting global research priorities for integrated community case management (iCCM): Results from a CHNRI (Child Health and Nutrition Research Initiative) exercise Aims To systematically identify global research gaps and resource priorities for integrated community case management (iCCM). Methods An iCCM Child Health and Nutrition Research Initiative (CHNRI) Advisory Group, in collaboration with the Community… 10/10/2014 Aims To systematically identify global research gaps and resource priorities for integrated community case management (iCCM). Methods An iCCM Child Health and Nutrition Research Initiative (CHNRI) Advisory Group, in collaboration with the Community Case Management Operational Research Group (CCM ORG) identified experts to…
19/09/2014 Journal article Novel approaches to risk stratification to support malaria elimination: An example from Cambodia Background Accurate malaria stratification is essential for effective targeting of interventions but represents a particular challenge in pre-elimination settings. In these settings transmission is typically sufficiently low and spatially heterogeneous to… 19/09/2014 Background Accurate malaria stratification is essential for effective targeting of interventions but represents a particular challenge in pre-elimination settings. In these settings transmission is typically sufficiently low and spatially heterogeneous to warrant a need for estimates of malaria risk at sub-district…
14/08/2014 Journal article Evaluation of community-based systems for the surveillance of day three-positive Plasmodium falciparum cases in western Cambodia Community-based surveillance of day-three Plasmodium falciparum cases is feasible, but highly intensive. It requires continuous support for supervision and training. 14/08/2014 Community-based surveillance of day-three Plasmodium falciparum cases is feasible, but highly intensive. It requires continuous support for supervision and training.
14/08/2014 Journal article “We are supposed to take care of it”: A qualitative examination of care and repair behaviour of long-lasting, insecticide-treated nets in Nasarawa state, Nigeria This study provides valuable insights into the perceptions and attitudes of users of long-lasting insecticidal nets in Nasarawa, Nigeria, on net durability, care and repair. 14/08/2014 This study provides valuable insights into the perceptions and attitudes of users of long-lasting insecticidal nets in Nasarawa, Nigeria, on net durability, care and repair.
07/07/2014 Journal article The use of counting beads to improve the classification of fast breathing in low-resource settings: a multi-country review This article presents findings on using counting beads and a timer to count a child's respiratory rate in order to improve classification of fast breathing. 07/07/2014 This article presents findings on using counting beads and a timer to count a child's respiratory rate in order to improve classification of fast breathing.
26/06/2014 Journal article Supervising community health workers in low-income countries: A review of impact and implementation issues Findings of this review suggest that high-quality supervision that focuses on supportive approaches, community monitoring, and/or quality assurance/problem -solving may be most effective for policy makers. 26/06/2014 Findings of this review suggest that high-quality supervision that focuses on supportive approaches, community monitoring, and/or quality assurance/problem -solving may be most effective for policy makers.
14/11/2013 Journal article Perceived quality of care for common childhood illnesses: Facility versus community based providers in Uganda Quality of care provided by community health workers is perceived to be higher than that of primary health facility workers in Uganda. 14/11/2013 Quality of care provided by community health workers is perceived to be higher than that of primary health facility workers in Uganda.
13/11/2013 Journal article Beyond Garki: monitoring changes in the epidemiology of malaria in the era of large scale interventions This abstract outlines the Beyond Garki project, which monitored long- and medium-term changes in the epidemiology of malaria. 13/11/2013 This abstract outlines the Beyond Garki project, which monitored long- and medium-term changes in the epidemiology of malaria.
10/09/2013 Journal article Universal coverage with insecticide-treated nets: Applying the revised indicators for ownership and use to the Nigeria 2010 malaria indicator survey data This study applies the newly recommended indicators for the evaluation of insecticide-treated net programmes to the data set from the Malaria Indicator Survey of Nigeria 2010. 10/09/2013 This study applies the newly recommended indicators for the evaluation of insecticide-treated net programmes to the data set from the Malaria Indicator Survey of Nigeria 2010.
09/09/2013 Journal article Mobile health (mHealth) approaches and lessons for increased performance and retention of community health workers in low-and middle-income countries: A review This study conducted a thematic review of how mHealth projects have approached the intersection of cellular technology and public health in low- and middle-income countries. 09/09/2013 This study conducted a thematic review of how mHealth projects have approached the intersection of cellular technology and public health in low- and middle-income countries.
19/12/2012 Journal article Malaria Policy Advisory Committee to the WHO: Conclusions and recommendations of September 2012 meeting This article provides a summary of the discussions, conclusions and recommendations from the meeting of the Malaria Policy Advisory Committee to the World Health Organization in September 2012. 19/12/2012 This article provides a summary of the discussions, conclusions and recommendations from the meeting of the Malaria Policy Advisory Committee to the World Health Organization in September 2012.
07/11/2012 Journal article Community acceptability and adoption of integrated community case management in Uganda Integrated community case management programmes require community sensitisation and targeted health systems strengthening to functioning optimally and enhance benefits such as reduced child mortality. 07/11/2012 Integrated community case management programmes require community sensitisation and targeted health systems strengthening to functioning optimally and enhance benefits such as reduced child mortality.
07/11/2012 Journal article Integrated community case management of fever in children under five using rapid diagnostic tests and respiratory rate counting: A multi-country cluster randomized trial This effectiveness trial, conducted in Burkina Faso, Ghana and Uganda, compared a diagnostic and treatment package for malaria and pneumonia with presumptive treatment with antimalarial drugs. 07/11/2012 This effectiveness trial, conducted in Burkina Faso, Ghana and Uganda, compared a diagnostic and treatment package for malaria and pneumonia with presumptive treatment with antimalarial drugs.
07/11/2012 Journal article Interventions to Improve Motivation and Retention of Community Health Workers Delivering Integrated Community Case Management (iCCM): Stakeholder Perceptions and Priorities Abstract Despite resurgence in the use of community health workers (CHWs) in the delivery of community case management of childhood illnesses, a paucity of evidence for effective strategies to address key… 07/11/2012 Abstract Despite resurgence in the use of community health workers (CHWs) in the delivery of community case management of childhood illnesses, a paucity of evidence for effective strategies to address key constraints of worker motivation and retention endures. This work reports…
07/11/2012 Journal article Introduction of Newborn Care within Integrated Community Case Management in Uganda Uganda’s Ministry of Health, together with partners, has introduced integrated community case management(iCCM) for children under 5 years. We assessed how the iCCM program addresses newborn care in threemidwestern districts… 07/11/2012 Uganda’s Ministry of Health, together with partners, has introduced integrated community case management(iCCM) for children under 5 years. We assessed how the iCCM program addresses newborn care in threemidwestern districts through document reviews, structured interviews, and focus group discussions with…
08/10/2012 Journal article Finding parasites and finding challenges: improved diagnostic access and trends in reported malaria and anti-malarial drug use in Livingstone district, Zambia Understanding the impact of malaria rapid diagnostic test (RDT) use on management of acute febrile disease at a community level, and on the consumption of anti-malarial medicines, is critical to… 08/10/2012 Understanding the impact of malaria rapid diagnostic test (RDT) use on management of acute febrile disease at a community level, and on the consumption of anti-malarial medicines, is critical to the planning and success of scale-up to universal parasite-based diagnosis…
01/10/2012 Journal article Focused Screening and Treatment (FSAT): A PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia The study reports that Focused Screening and Treatment is a potentially useful tool to detect, treat and track clusters of asymptomatic carriers of P. falciparum, and to provide valuable epidemiological… 01/10/2012 The study reports that Focused Screening and Treatment is a potentially useful tool to detect, treat and track clusters of asymptomatic carriers of P. falciparum, and to provide valuable epidemiological information regarding cross-border movements of potential parasite carriers.
11/07/2012 Journal article Community Health Workers Use Malaria Rapid Diagnostic Tests (RDTs) Safely and Accurately: Results of a Longitudinal Study in Zambia Malaria rapid diagnostic tests (RDTs) could radically improve febrile illness management in remote and low-resource populations. However, reliance upon community health workers (CHWs) remains controversial because of concerns about blood… 11/07/2012 Malaria rapid diagnostic tests (RDTs) could radically improve febrile illness management in remote and low-resource populations. However, reliance upon community health workers (CHWs) remains controversial because of concerns about blood safety and appropriate use of artemisinin combination therapy. This study…
07/06/2012 Journal article A stitch in time: a cross-sectional survey looking at long lasting insecticide-treated bed net ownership, utilization and attrition in SNNPR, Ethiopia Since 2002/03, an estimated 4.7 million nets have been distributed in the Southern Nations, Nationalities and Peoples Region (SNNPR) among an at risk population of approximately 10 million people. Evidence… 07/06/2012 Since 2002/03, an estimated 4.7 million nets have been distributed in the Southern Nations, Nationalities and Peoples Region (SNNPR) among an at risk population of approximately 10 million people. Evidence from the region suggests that large-scale net ownership rapidly increased…
20/04/2012 Journal article Programme level implementation of malaria rapid diagnostic tests (RDTs) use: outcomes and cost of training health workers at lower level health care facilities in Uganda The training of health workers in the use of malaria rapid diagnostic tests (RDTs) is an important component of a wider strategy to improve parasite-based malaria diagnosis at lower level… 20/04/2012 The training of health workers in the use of malaria rapid diagnostic tests (RDTs) is an important component of a wider strategy to improve parasite-based malaria diagnosis at lower level health care facilities (LLHFs) where microscopy is not readily available…
20/04/2012 Journal article Access, acceptability and utilization of community health workers using diagnostics for case management of fever in Ugandan children: a cross-sectional study Use of diagnostics in integrated community case management (iCCM) of fever is recognized as an important step in improving rational use of drugs and quality of care for febrile under-five… 20/04/2012 Use of diagnostics in integrated community case management (iCCM) of fever is recognized as an important step in improving rational use of drugs and quality of care for febrile under-five children. This study conducted in the Ugandan District of Iganga,…
10/04/2012 Journal article Prevalence of trachoma in Unity state, South Sudan: Results from a large-scale population-based survey and potential implications for further surveys Abstract Large parts of South Sudan are thought to be trachoma endemic but baseline data, required to initiate interventions, are few. District-by-district surveys, currently recommended by the World Health Organization (WHO),… 10/04/2012 Abstract Large parts of South Sudan are thought to be trachoma endemic but baseline data, required to initiate interventions, are few. District-by-district surveys, currently recommended by the World Health Organization (WHO), are often not financially or logistically viable. We therefore adapted…
01/02/2012 Journal article Can universal insecticide-treated net campaigns achieve equity in coverage and use? The case of northern Nigeria Insecticide-treated nets (ITNs) are effective tools for malaria prevention and can significantly reduce severe disease and mortality due to malaria, especially among children under five in endemic areas. However, ITN… 01/02/2012 Insecticide-treated nets (ITNs) are effective tools for malaria prevention and can significantly reduce severe disease and mortality due to malaria, especially among children under five in endemic areas. However, ITN coverage and use remain low and inequitable among different socio-economic…
23/01/2012 Journal article Early experiences on the feasibility, acceptability and use of malaria rapid diagnostic tests at peripheral health centres in Uganda: Insights into some barriers and facilitators Abstract While feasibility of new health technologies in well-resourced healthcare settings is extensively documented, it is largely unknown in low-resourced settings. Uganda’s decision to deploy and scale up malaria rapid diagnostic… 23/01/2012 Abstract While feasibility of new health technologies in well-resourced healthcare settings is extensively documented, it is largely unknown in low-resourced settings. Uganda’s decision to deploy and scale up malaria rapid diagnostic tests (mRDTs) in public health facilities and at the community…
18/01/2012 Journal article Plasmodium–Helminth coinfection and its sources of heterogeneity across East Africa Abstract Plasmodium–helminth coinfection can have a number of consequences for infected hosts, yet our knowledge of the epidemiology of coinfection across multiple settings is limited. This study investigates the distribution and… 18/01/2012 Abstract Plasmodium–helminth coinfection can have a number of consequences for infected hosts, yet our knowledge of the epidemiology of coinfection across multiple settings is limited. This study investigates the distribution and heterogeneity of coinfection with Plasmodium falciparum and 3 major helminth…
18/10/2011 Journal article Placental Plasmodium falciparum malaria infection: Operational accuracy of HRP2 rapid diagnostic tests in a malaria endemic setting Abstract Malaria has a negative effect on the outcome of pregnancy. Pregnant women are at high risk of severe malaria and severe haemolytic anaemia, which contribute over 60-70 percent of foetal… 18/10/2011 Abstract Malaria has a negative effect on the outcome of pregnancy. Pregnant women are at high risk of severe malaria and severe haemolytic anaemia, which contribute over 60-70 percent of foetal and perinatal losses. Infection with P. falciparum towards the end…
13/10/2011 Journal article Evidence for a useful life of more than three years for a polyester-based long-lasting insecticidal mosquito net in western Uganda Abstract Long-lasting insecticidal nets (LLIN) are now standard for the prevention of malaria. However, only products with recommendation for public use from the World Health Organization should be used and this… 13/10/2011 Abstract Long-lasting insecticidal nets (LLIN) are now standard for the prevention of malaria. However, only products with recommendation for public use from the World Health Organization should be used and this evaluation includes the assessment of net effectiveness after three years…
11/10/2011 Journal article The cost of antibiotic mass drug administration for trachoma control in a remote area of South Sudan To inform budgeting to scale up control of trachoma and other NTDs relying on large-scale mass drug administration, this study set out to determine the cost per person treated when… 11/10/2011 To inform budgeting to scale up control of trachoma and other NTDs relying on large-scale mass drug administration, this study set out to determine the cost per person treated when antibiotics were delivered via a campaign in South Sudan.
01/09/2011 Journal article Accuracy of circulating cathodic antigen tests for rapid mapping of Schistosoma mansoni and S. haematobium infections in Southern Sudan Programmes aiming to control or eliminate neglected tropical diseases (NTDs) are being scaled up in many parts of the world. As part of this ongoing effort, many countries still need… 01/09/2011 Programmes aiming to control or eliminate neglected tropical diseases (NTDs) are being scaled up in many parts of the world. As part of this ongoing effort, many countries still need to complete mapping of their NTD endemic areas. This study…
15/07/2011 Journal article The impact of mass drug administration and long-lasting insecticidal net distribution on Wuchereria bancrofti infection in humans and mosquitoes: An observational study in Northern Uganda This study aimed to investigate whether large-scale distribution of long-lasting insecticidal nets could contribute towards the mass drug administration-based transmission control of lymphatic filariasis. 15/07/2011 This study aimed to investigate whether large-scale distribution of long-lasting insecticidal nets could contribute towards the mass drug administration-based transmission control of lymphatic filariasis.
14/07/2011 Journal article Can lay community health workers be trained to use diagnostics to distinguish and treat malaria and pneumonia in children? Lessons from rural Uganda This study sought to determine the competence of community health workers in Uganda to correctly assess, classify and treat malaria and pneumonia among under-five children after training. 14/07/2011 This study sought to determine the competence of community health workers in Uganda to correctly assess, classify and treat malaria and pneumonia among under-five children after training.
30/06/2011 Journal article Mortality after fluid bolus in African children with severe infection Abstract The role of fluid resuscitation in the treatment of children with shock and life threatening infections who live in resource-limited settings is not established. Thus, the study randomly assigned children… 30/06/2011 Abstract The role of fluid resuscitation in the treatment of children with shock and life threatening infections who live in resource-limited settings is not established. Thus, the study randomly assigned children with severe febrile illness and impaired perfusion to receive boluses…
01/03/2011 Journal article Case Management of Severe Malaria - A Forgotten Practice: Experiences from Health Facilities in Uganda Severe malaria is a life-threatening medical emergency and requires prompt and effective treatment to prevent death. However, effective management of severe malaria is relatively expensive and relies heavily on well… 01/03/2011 Severe malaria is a life-threatening medical emergency and requires prompt and effective treatment to prevent death. However, effective management of severe malaria is relatively expensive and relies heavily on well equipped hospitals, with adequately trained health workers, both often lacking…
25/01/2011 Journal article A Research agenda for malaria eradication: Monitoring, evaluation and surveillance Abstract Monitoring, evaluation, and surveillance measure how well public health programs operate over time and achieve their goals. This report of the malERA Consultative Group on Monitoring, Evaluation, and Surveillance, focuses… 25/01/2011 Abstract Monitoring, evaluation, and surveillance measure how well public health programs operate over time and achieve their goals. This report of the malERA Consultative Group on Monitoring, Evaluation, and Surveillance, focuses on defining the monitoring and evaluation and surveillance research and…
16/12/2010 Journal article The clinical impact of combining intermittent preventive treatment with home management of malaria in children aged below five years: Cluster randomised trial This study aimed to investigate the impact of seasonal intermittent preventive treatment on malaria-related morbidity in children under five who already had access to home-based management of malaria for presumptive… 16/12/2010 This study aimed to investigate the impact of seasonal intermittent preventive treatment on malaria-related morbidity in children under five who already had access to home-based management of malaria for presumptive treatment of fevers.
18/11/2010 Journal article How many mosquito nets are needed to achieve universal coverage? Recommendations for the quantification and allocation of long-lasting insecticidal nets for mass campaigns Abstract Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns… 18/11/2010 Abstract Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns in several countries have run out of nets in the…
15/11/2010 Journal article Antimicrobial agents and chemotherapy: Limited ability of Plasmodium falciparum Pfcrt, Pfmdr1, and Pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda Abstract Quinine is a standard drug for treating severe malaria in Africa, and it is also increasingly used to treat uncomplicated disease. However, failures of quinine therapy are common, and it… 15/11/2010 Abstract Quinine is a standard drug for treating severe malaria in Africa, and it is also increasingly used to treat uncomplicated disease. However, failures of quinine therapy are common, and it is unknown if failures in Africa are due to drug…
27/10/2010 Journal article Performance of three multi-species rapid diagnostic tests for diagnosis of Plasmodium falciparum and Plasmodium vivax malaria in Oromia Regional State, Ethiopia Abstract Malaria transmission in Ethiopia is unstable and variable, caused by both Plasmodium falciparum and Plasmodium vivax. The Federal Ministry of Health (FMoH) is scaling up parasitological diagnosis of malaria at… 27/10/2010 Abstract Malaria transmission in Ethiopia is unstable and variable, caused by both Plasmodium falciparum and Plasmodium vivax. The Federal Ministry of Health (FMoH) is scaling up parasitological diagnosis of malaria at all levels of the health system; at peripheral health facilities…
01/10/2010 Journal article Trachoma rapid assessments in Unity and Northern Bahr-el-Ghazal states, Southern Sudan Abstract Trachoma is thought to be endemic over large parts of Southern Sudan, but empirical evidence is limited. While some areas east of the Nile have been identified as highly endemic,… 01/10/2010 Abstract Trachoma is thought to be endemic over large parts of Southern Sudan, but empirical evidence is limited. While some areas east of the Nile have been identified as highly endemic, few trachoma surveys have been conducted in the remainder of…
17/08/2010 Journal article Targeting trachoma control through risk mapping: The example of southern Sudan This study sought to develop maps to help target the available resources for trachoma surveys and interventions in southern Sudan to areas where they are most needed, thereby improving programme… 17/08/2010 This study sought to develop maps to help target the available resources for trachoma surveys and interventions in southern Sudan to areas where they are most needed, thereby improving programme efficiency.
13/07/2010 Journal article Community acceptability of use of rapid diagnostic tests for malaria by community health workers in Uganda Abstract Many malarious countries plan to introduce artemisinin combination therapy (ACT) at community level using community health workers (CHWs) for treatment of uncomplicated malaria. Use of ACT with reliance on presumptive… 13/07/2010 Abstract Many malarious countries plan to introduce artemisinin combination therapy (ACT) at community level using community health workers (CHWs) for treatment of uncomplicated malaria. Use of ACT with reliance on presumptive diagnosis may lead to excessive use, increased costs and rise…
13/07/2010 Journal article Integrated surveys of neglected tropical diseases in southern Sudan: How much do they cost and can they be refined? Abstract Control of neglected tropical diseases (NTDs) is suggested to be more cost-effective when drugs are co-administered through a single integrated delivery system rather than separate systems. An essential prerequisite for… 13/07/2010 Abstract Control of neglected tropical diseases (NTDs) is suggested to be more cost-effective when drugs are co-administered through a single integrated delivery system rather than separate systems. An essential prerequisite for such efficiency gains is sufficient geographical overlap of the targeted…
12/07/2010 Journal article Use of RDTs to improve malaria diagnosis and fever case management at primary healthcare facilities in Uganda This study evaluated the effect of malaria rapid diagnostic tests on health workers' antimalarial drug prescriptions among outpatients at low-level health care facilities within different malaria epidemiological settings in… 12/07/2010 This study evaluated the effect of malaria rapid diagnostic tests on health workers' antimalarial drug prescriptions among outpatients at low-level health care facilities within different malaria epidemiological settings in Uganda.
29/06/2010 Journal article How to (or not to) integrate vertical programmes for the control of major neglected tropical diseases in sub-Saharan Africa Abstract Combining the delivery of multiple health interventions has the potential to minimize costs and expand intervention coverage. Integration of mass drug administration is therefore being encouraged for delivery of preventive… 29/06/2010 Abstract Combining the delivery of multiple health interventions has the potential to minimize costs and expand intervention coverage. Integration of mass drug administration is therefore being encouraged for delivery of preventive chemotherapy (PCT) to control onchocerciasis, lymphatic filariasis, schistosomiasis, soil-transmitted helminthiasis,…
18/06/2010 Journal article System effectiveness of a targeted free mass distribution of long-lasting insecticidal nets in Zanzibar, Tanzania A targeted mass distribution of free LLINs to children under five and pregnant women was implemented in Zanzibar between August 2005 and January 2006. This study evaluates the outcomes… 18/06/2010 A targeted mass distribution of free LLINs to children under five and pregnant women was implemented in Zanzibar between August 2005 and January 2006. This study evaluates the outcomes of this distribution post implementation.
20/04/2010 Journal article Costs and effects of two public sector delivery channels for long-lasting insecticidal nets in Uganda Abstract In Uganda, long-lasting insecticidal nets (LLIN) have been predominantly delivered through two public sector channels: targeted campaigns or routine antenatal care (ANC) services. Their combination in a mixed-model strategy is… 20/04/2010 Abstract In Uganda, long-lasting insecticidal nets (LLIN) have been predominantly delivered through two public sector channels: targeted campaigns or routine antenatal care (ANC) services. Their combination in a mixed-model strategy is being advocated to quickly increase LLIN coverage and maintain it…
24/03/2010 Journal article Evaluation of interceptor long-lasting insecticidal nets in eight communities in Liberia Abstract There has been a renewed emphasis on preventive measures for malaria at community and individual levels. Long-lasting insecticidal nets (LLINs) have been strongly advocated for use to prevent malaria in… 24/03/2010 Abstract There has been a renewed emphasis on preventive measures for malaria at community and individual levels. Long-lasting insecticidal nets (LLINs) have been strongly advocated for use to prevent malaria in sub-Saharan Africa and are considered to be a significant improvement…
01/03/2010 Journal article Review of delivery strategies for insecticide treated mosquito nets – are we ready for the next phase of malaria control efforts? This review found that campaign distributions that target the general population are best suited for the scale-up phase of universal access to long-lasting insecticidal nets. 01/03/2010 This review found that campaign distributions that target the general population are best suited for the scale-up phase of universal access to long-lasting insecticidal nets.
01/02/2010 Journal article An assessment of lot quality assurance sampling to evaluate malaria outcome indicators: Extending malaria indicator surveys Abstract Large investments and increased global prioritization of malaria prevention and treatment have resulted in greater emphasis on programme monitoring and evaluation (M&E) in many countries. Many countries currently use… 01/02/2010 Abstract Large investments and increased global prioritization of malaria prevention and treatment have resulted in greater emphasis on programme monitoring and evaluation (M&E) in many countries. Many countries currently use large multistage cluster sample surveys to monitor malaria outcome indicators…
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