Thank you for downloading this publication. Please let us know why you chose this publication:
Why are you interested in this publication?
What organisation do you represent?
You will only need to complete this form once per browser/device
How do you prefer to read or receive publications?

We may contact you for feedback on the publication you have downloaded. If you do not want to be contacted, please leave the email field blank. Your information will never be shared with any third party.

Donate Visit Malaria Consortium U.S.
  • Visit Malaria Consortium U.S.
  • What we do
    • Diseases
    • Policy development and advocacy
    • Research
    • Learning
  • Our expertise
  • Where We Work
    • Africa
    • Burkina Faso
    • Chad
    • Ethiopia
    • Mozambique
    • Nigeria
    • South Sudan
    • Uganda
    • Asia
    • Cambodia
    • Myanmar
    • Thailand
  • Projects
    • Project database
    • Featured projects
    • Past projects
  • Publications
  • Media centre
    • Newsletters
    • News
    • Blog
    • Videos
    • Webinars
    • Press and media
    • Photo stories
    • Voices of experience
  • About us
    • Who we are
    • Governance
    • Aid transparency
    • Dr Sylvia Meek
    • Annual reviews
    • Policies and procedures
    • Careers
    • Tenders
    • Contact us
    • Malaria Consortium U.S.
  • Support us
  • Home
  • »
  • Resources
  • »
  • Publications
  • »
  • Focused Screening and Treatment (FSAT): A PCR-Based Strategy to Detect Malaria Parasite Carriers and Contain Drug Resistant P. falciparum, Pailin, Cambodia

Share this page

Resources

Latest

Publications

Publication Date:
01/10/2012

Type:
Journal article
Publication

Focused Screening and Treatment (FSAT): A PCR-Based Strategy to Detect Malaria Parasite Carriers and Contain Drug Resistant P. falciparum, Pailin, Cambodia
Author(s): Stefan Hoyer, Sokomar Nguon, Saorin Kim, Najibullah Habib, Nimol Khim, Sarorn Sum, Eva- Maria Christophel, Steven Bjorge, Andrew Thomson, Sim Kheng, Nguon Chea, Sovann Yok, Samphornarann Top, Seyha Ros, Uth Sophal, Michelle M. Thompson, Steve Mellor, Frederic Ariey, Benoit Witkowski, Chhiang Yeang, Shunmay Yeung, Socheat Duong, Robert D. Newman, Didier Menard

Publication Date:
01/10/2012
Type:
Journal article

Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P.falciparum populations and to assess the risk of the possible spread of these parasites outside Pailin, a new epidemiological tool named ‘‘Focused Screening and Treatment’’ (FSAT), based on active molecular detection of asymptomatic parasite carriers was introduced in 2010. Cross-sectional malariometric surveys using PCR were carried out in 20 out of 109 villages in Pailin province. Individuals detected as P. falciparum carriers were treated with atovaquone-proguanil combination plus a single dose of primaquine if the patient was non-G6PD deficient. Interviews were conducted to elicit history of cross-border travel that might contribute to the spread of artemisinin-resistant parasites. Retrospective analysis, using 2010 routine surveillance data, showed significant differences in the prevalence of asymptomatic carriers discovered by FSAT between villages classified as ‘‘high risk’’ and ‘‘low risk’’ based on malaria incidence data. All positive individuals treated and followed-up until day 28 were cured. No mutant-type allele related to atovaquone resistance was found. The study reports that FSAT is a potentially useful tool to detect, treat and track clusters of asymptomatic carriers of P. falciparum along with providing valuable epidemiological information regarding cross-border movements of potential malaria parasite carriers and parasite gene flow.

Click here to download

Country: Cambodia

Keywords: Surveillance | Case management | Resistance management

 

 

« Back to Publications

Sign up for our publications newsletter here:

Sign up for our newsletters here:

  • Visit Malaria Consortium U.S.
  • What we do
    • Diseases
    • Policy development and advocacy
    • Research
    • Learning
  • Our expertise
  • Where We Work
    • Africa
    • Burkina Faso
    • Chad
    • Ethiopia
    • Mozambique
    • Nigeria
    • South Sudan
    • Uganda
    • Asia
    • Cambodia
    • Myanmar
    • Thailand
  • Projects
    • Project database
    • Featured projects
    • Past projects
  • Publications
  • Media centre
    • Newsletters
    • News
    • Blog
    • Videos
    • Webinars
    • Press and media
    • Photo stories
    • Voices of experience
  • About us
    • Who we are
    • Governance
    • Aid transparency
    • Dr Sylvia Meek
    • Annual reviews
    • Policies and procedures
    • Careers
    • Tenders
    • Contact us
    • Malaria Consortium U.S.
  • Support us

Language Options: English | Français

© 2022 Malaria Consortium | Charity No. 1099776 | Company No. 4785712 | Privacy notice | Modern Slavery Statement | United Nations Global Compact