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  • Performance of five pulse oximeters to detect hypoxaemia as an indicator of severe illness in children under five by frontline health workers in low-resource settings

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Publication Date:
23/07/2021

Type:
Journal article
Publication

Performance of five pulse oximeters to detect hypoxaemia as an indicator of severe illness in children under five by frontline health workers in low-resource settings
Author(s): Kevin Baker, Max Petzold, Akasiima Mucunguzi, Alexandra Wharton-Smith, Emily Dantzer, Tedila Habte, Lena Matata, Diana Nanyumba, Morris Okwir, Monica Posada, Anteneh Sebsibe, Jill Nicholson, Madeleine Marasciulo, Rasa Izadnegahdar, Tobias Alfven, Karin Kallander

Publication Date:
23/07/2021
Type:
Journal article

Background

Low blood oxygen saturation (SpO2), or hypoxaemia, is an indicator of severe illness in children. Pulse oximetry is a globally accepted, non-invasive method to identify hypoxaemia, but rarely available outside higher-level facilities in resource-constrained countries. This study aims to evaluate the performance of different types of pulse oximeters amongst frontline health workers in Cambodia, Ethiopia, South Sudan and Uganda.

Methods

Five pulse oximeters (POx) which passed laboratory testing, out of an initial 32 potential pulse oximeters, were evaluated by frontline health workers for performance, defined as agreement between the SpO2 measurements of the test device and the reference standard. 

Findings

Two finger-tip pulse oximeters (Contec and Devon), two handheld pulse oximeters (Lifebox and Utech) and one phone pulse oximeter (Masimo) passed the laboratory testing. They were evaluated for performance on 1,313 children under five years by 207 frontline health workers between February and May 2015. Phone and handheld pulse oximeters had greater overall agreement with the reference standard (56 percent; 95 percent CI 0.52–0.60 to 68 percent; 95 percent CI 0.65–0.71) than the finger-tip POx (31 percent; 95 percent CI 0.26 to 0.36 and 47 percent; 95 percent CI 0.42 to 0.52). Fingertip POx performance was substantially lower in the 0–2 month olds; having just 17 percent and 25 percent agreement. The finger-tip devices more often underreported SpO2 readings (mean difference -7.9 percent; 95 percent CI -8.6,-7.2 and -3.9 percent; 95 percent CI -4.4,-3.4), and therefore over-diagnosed hypoxaemia in the children assessed.

Interpretation

While the Masimo phone pulse oximeter performed best, all handheld POx with age-specific probes performed well in the hands of frontline health workers, further highlighting their suitability as a screening tool of severe illness. The poor performance of the fingertip POx suggests they should not be used in children under five by frontline health workers. It is essential that POx are performance tested on children in routine settings (in vivo), not only in laboratories or controlled settings (in vitro), before being introduced at scale.

Published in EClinicalMedicine

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Country: Cambodia | Ethiopia | South Sudan | Uganda

Keywords: Community delivery | Costing and economic impact evaluation | Research | Pneumonia | Diagnosis | SDG3

 

 

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