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PMC Effect: Nigeria operational feasibility and effectiveness of PMC (formerly IPTi)

This study will assess the clinical effectiveness and operational feasibility of perennial malaria chemoprevention (PMC), previously referred to as IPTi, in Nigeria. It aims to generate the necessary evidence to support the intervention’s uptake in the national health policy. 

The project has two main objectives: 

Evaluate the impact of PMC on key child health outcomes including malaria cases and deaths, hospitalisations, anaemia and safety 

Assess the operational feasibility of PMC by determining the cost of introducing PMC in Nigeria, how best to adapt the strategy to optimise impact, and whether high uptake can be achieved.

 

Start date
01/12/2020
End date
31/10/2024
Country/
Countries
Africa > Nigeria
Funder
Bill & Melinda Gates Foundation
Funding
4000000.00 (USD)
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Children gather for a photograph in Edati LGA, Niger state, Nigeria

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Publications: Reducing malaria morbidity in infants through perennial malaria chemoprevention in Nigeria
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Investigating factors enabling the acceptability of perennial malaria chemoprevention implementation in Osun State, Nigeria: Evidence from a qualitative process evaluation

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Is perennial malaria chemoprevention cost-effective? Evidence from integrated delivery with routine immunisation in Nigeria

Perennial malaria chemoprevention is a cost-effective intervention for reducing malaria morbidity and mortality among children under two years in Nigeria and supports policy consideration for national scale-up.
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Operational feasibility, acceptability and coverage of perennial malaria chemoprevention: The Nigeria experience

The success of perennial malaria chemoprevention depends on strong operational systems to enable delivery, and high acceptability to promote uptake.
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The impact of perennial malaria chemoprevention on key health outcomes in children aged 2–18 months: Results from a cluster-randomised controlled trial in Nigeria

Perennial malaria chemoprevention is associated with reductions in all-cause consultations, cases of clinical malaria and cases of severe malaria; improved coverage is expected to lead to greater impact.
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Perceived barriers and enablers for sulfadoxine-pyrimethamine perennial malaria chemoprevention implementation in Osun state: A qualitative analysis of the process evaluation study

Effective scale-up of perennial malaria chemoprevention in Nigeria requires addressing health system gaps, strengthening caregiver awareness and deepening community engagement.
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Caregivers, community leaders and health workers' perspectives on the effectiveness of perennial malaria chemoprevention in Osun state, Nigeria: A qualitative study in process evaluation

Caregivers, community leaders and health workers perceived perennial malaria chemoprevention as effective in reducing malaria among children, enhancing community participation and alleviating the disease burden through sustained preventive health engagement.
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Avoiding missed opportunities for perennial malaria chemoprevention: A systematic review of factors influencing the uptake of three other maternal and child health interventions

There is limited evidence on the causes of missed opportunities for perennial malaria chemoprevention (PMC). However, available evidence on the causes of missed opportunities for intermittent preventive treatment in pregnancy, vitamin A supplementation and childhood vaccination can contribute to developing a framework for further research on PMC.
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Utilising the COM-B behaviour change model to increase the uptake of perennial malaria chemoprevention and routine immunisation in Nigeria

Social and behaviour change that creates not just awareness, but sustained capacity, motivation and opportunity, is essential to realise the full potential of perennial malaria chemoprevention in reducing malaria morbidity and mortality.
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Sulfadoxine-pyrimethamine resistance study

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