A cluster randomised controlled trial to compare sulfadoxine-pyrimethamine and amodiaquine with dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in Karamoja region, Uganda

Both sulfadoxine-pyrimethamine plus amodiaquine and dihydroartemisinin-piperaquine are highly effective in preventing clinical malaria in eligible children during the high transmission season.

Modelling suggests seasonal malaria chemoprevention (SMC) would be effective in preventing malaria in the Karamoja region of Uganda, where transmission is seasonal and prevalence rates are the highest in the country. We carried out a cluster randomised controlled trial to assess the effectiveness of sulfadoxine-pyrimethamine plus amodiaquine in children 3–59 months and dihydroartemisinin-piperaquine in children 6–59 months, respectively.

This oral presentation was given at the Multilateral Initiative on Malaria (MIM) Society's 8th Pan-African Malaria Conference.

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Country: Uganda

Keywords: Malaria | SMC