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  • Assessment of the feasibility, acceptability and impact of implementing seasonal malaria chemoprevention in Nampula Province, Mozambique: Protocol for a hybrid effectiveness-implementation study

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Publication Date:
17/09/2021

Type:
Journal article
Publication

Assessment of the feasibility, acceptability and impact of implementing seasonal malaria chemoprevention in Nampula Province, Mozambique: Protocol for a hybrid effectiveness-implementation study
Author(s): Alexandra Wharton-Smith, Kevin Baker, Arantxa Roca-Feltrer, Maria Rodrigues, Sol Richardson, Craig A Bonnington, Christian Rassi, Madeleine Marasciulo, Sonia Enosse, Francisco Saute, Pedro Aide, Eusebio Macete, Baltazar Candrinho

Publication Date:
17/09/2021
Type:
Journal article

Background

Malaria is a significant cause of morbidity and mortality in children aged under five in Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration of four monthly courses of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ), to children aged 3–59 months during rainy season. However, as resistance to SP is widespread in East and Southern Africa, SMC has so far only been implemented across the Sahel in West Africa.

Objective

This protocol describes the first phase of a pilot project that aims to assess the protective effect of SP and AQ when used for SMC and investigate the levels of molecular markers of resistance of Plasmodium falciparum to antimalarial medicines in the study districts. In addition, it is important to understand whether SMC is a feasible and acceptable intervention in the context of Nampula Province, Mozambique.

Methods

This study will adopt a hybrid effectiveness-implementation design to conduct a mixed methods evaluation with six objectives: a molecular marker study; a nonrandomized controlled trial; an analysis of reported malaria morbidity indicators; a documentation exercise of the contextual SMC adaptation; an acceptability and feasibility assessment and a coverage and quality assessment.

Results

Ethical approval for this study was granted by the Mozambican Ministry of Health National Bioethics Committee on 15th September 2020. Data collection began in October 2020.

Conclusions

This research will make a unique contribution to our understanding of whether the combination of SP and AQ, when used for SMC, can confer a protective effect against malaria in children aged 3–59 months in a region where malaria transmission is seasonal and SP resistance is expected to be high. If the project is successful, subsequent phases are expected to provide a more comprehensive assessment of the effectiveness and sustainability of SMCs.

Published in JMIR Research Protocols 

Click here to download

Country: Mozambique

Keywords: Research | Malaria | Seasonal malaria chemoprevention | SDG3

 

 

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