To reduce malaria morbidity and mortality in infants, the World Health Organization (WHO) recommends intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine in areas with moderate to high malaria transmission. However, a decade after WHO’s recommendation, only one country has adopted the strategy as national policy, and various barriers to IPTi policy uptake remain. This study will assess IPTi’s clinical effectiveness and operational feasibility in Nigeria. It aims to generate the necessary evidence to support the intervention’s uptake in the national health policy.
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